Association between ovarian volume and serum insulin levels in ovulatory patients with idiopathic hirsutism.

We assessed the influence of insulin on ovarian volume in 45 women with regular, ovulatory menstrual cycles, normal androgen levels, and isolated hirsutism (idiopathic hirsutism). Insulin levels, insulin-to-glucose ratio, and homeostasis model assessment (HOMA) were significantly higher in patients with ovarian volume >9 cm3 than in women with smaller ovaries (P<.05), and insulin levels presented a significant positive correlation with ovarian volume (r = 0.37, P=.02), which was independent of body mass index (BMI) or the luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio.