Communications biology · 2020
The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries).
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Sakthivel Dhanasekaran, Preston Sarah, Gasser Robin B, Costa Tatiana P Soares da, Hernandez Julia N, Shahine Adam, Shakif-Azam M D, Lock Peter, Rossjohn Jamie, Perugini Matthew A, González Jorge Francisco, Meeusen Els, Piedrafita David, Beddoe Travis
Аннотация
Galectins are a family of glycan-binding molecules with a characteristic affinity for ß-D-glycosides that mediate a variety of important cellular functions, including immune and inflammatory responses. Galectin-11 (LGALS-11) has been recently identified as a mediator induced specifically in animals against gastrointestinal nematodes and can interfere with parasite growth and development. Here, we report that at least two natural genetic variants of LGALS-11 exist in sheep, and demonstrate fundamental differences in anti-parasitic activity, correlated with their ability to dimerise. This study improves our understanding of the role of galectins in the host immune and inflammatory responses against parasitic nematodes and provides a basis for genetic studies toward selective breeding of animals for resistance to parasites.