Journal of ophthalmic inflammation and infection · 2013
Use of linseed oil to treat experimentally induced keratoconjunctivitis sicca in rabbits.
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Neves Magda Luzia, Yamasaki Letícia, Sanches Osimar de Carvalho, do Amaral Marcelo Sávio Paiva, Stevanin Helaine, Giuffrida Rogério, Candido Eudes Ramalho, Góes Jonatas Eduardo, Zulim Luís Felipe da Costa, Schweigert Augusto, Fukui Rosimery Missuzu, Meirelles Carlos Collares, Sasaki Carolina Akemi, Andrade Silvia Franco
Аннотация
BACKGROUND: The objective of this study was to evaluate the effectiveness of various linseed oil (LO) preparations (oral, topical, oral and topical combined) in treating experimentally induced keratoconjunctivitis sicca (KCS) in rabbits. Twenty male New Zealand white rabbits were divided into four groups: group C (control), group OLO (oral LO), group TLO (topical LO), and group OTLO (oral and topical LO). The animals were evaluated weekly using Schirmer's tear test (STT), fluorescein test (FT), and Rose Bengal test (RBT) and were euthanized at the end of the experiment for histopathological analysis.
FINDINGS: There were significant improvements in the parameters analyzed (STT, FT, and RBT) and in the histopathological finding in all of the groups using LO.
CONCLUSIONS: The analyzed results demonstrate that LO, administered orally or topically, was effective in treating experimentally induced KCS in rabbits, although combined oral and topical LO did not show additional benefits greater than those with a single route of administration.
FINDINGS: There were significant improvements in the parameters analyzed (STT, FT, and RBT) and in the histopathological finding in all of the groups using LO.
CONCLUSIONS: The analyzed results demonstrate that LO, administered orally or topically, was effective in treating experimentally induced KCS in rabbits, although combined oral and topical LO did not show additional benefits greater than those with a single route of administration.