Nature communications · 2020
The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Verity Robert, Aydemir Ozkan, Brazeau Nicholas F, Watson Oliver J, Hathaway Nicholas J, Mwandagalirwa Melchior Kashamuka, Marsh Patrick W, Thwai Kyaw, Fulton Travis, Denton Madeline, Morgan Andrew P, Parr Jonathan B, Tumwebaze Patrick K, Conrad Melissa, Rosenthal Philip J, Ishengoma Deus S, Ngondi Jeremiah, Gutman Julie, Mulenga Modest, Norris Douglas E, Moss William J, Mensah Benedicta A, Myers-Hansen James L, Ghansah Anita, Tshefu Antoinette K, Ghani Azra C, Meshnick Steven R, Bailey Jeffrey A, Juliano Jonathan J
Аннотация
The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequence 2537 Plasmodium falciparum infections, including a nationally representative population sample from DRC and samples from surrounding countries, using molecular inversion probes - a high-throughput genotyping tool. We identify an east-west divide in haplotypes known to confer resistance to chloroquine and sulfadoxine-pyrimethamine. Furthermore, we identify highly related parasites over large geographic distances, indicative of gene flow and migration. Our results are consistent with a background of isolation by distance combined with the effects of selection for antimalarial drug resistance. This study provides a high-resolution view of parasite genetic structure across a large country in Africa and provides a baseline to study how implementation programs may impact parasite populations.