The Australasian journal of dermatology · 2012
A case of pemphigoid gestationis with concurrent IgG antibodies to BP180, BP230 and type VII collagen.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Yang Baoqi, Wang Chong, Wu Mei, Du Donghong, Yan Xiaoxiao, Zhou Guizhi, Zhang Furen
Аннотация
A 22-year-old primigravida had a pruritic, erythematous, bullous eruption on the skin during the 26th week of gestation. After delivery the eruption flared up. The diagnosis of pemphigoid gestationis was confirmed based on histopathological and immunofluorescence findings. The result of immunoblotting showed IgG autoantibodies which reacted against BP230 in epidermal extracts and 290 kDa type VII collagen in dermal extracts. The BP180 antibodies were also detected by an enzyme-linked immunosorbent assay BP180NC16a diagnosis kit. Pulsed corticosteroid and cyclophosphamide resulted in a favourable response at the acute stage. The patient was cured in 2 years. The analysis of the patient's autoantibodies provides strong evidence for the involvement of epitope spreading in her autoimmune disease.