[The effect of obzidan on the cardiohemodynamics of subjects with an artificial pacemaker who have hypertension].

Overall thirty six persons with artificial pacemaker (AP), presenting with stage I-II hypertensive disease were examined. Effects of obzidan on cardiohemodynamics (CHD) were studied with single administration and course treatment over two weeks depending on the type of circulation. In hyperkinetic type effects of obzidan on AP and CHD were more pronounced than in eu- and hypokinetic types. But latter subjects developed clinical signs of cardiac insufficiency growing progressively worse. It was found out that cardiohemodynamic effects of obzidan in patients with AP depend upon particular features of intracardiac hemodynamics in ventricular electric stimulation (fixed cardiac rhythm, atrioventricular dissociation, pathologic asynchrony of ventricles) and initial type of circulation.