Frontiers in cardiovascular medicine · 2026
Recurrent myocarditis in a young female with a desmoplakin gene variant: a case report and literature review.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Liu Chenxi, Wen Wen, Qu Mingyue, Jin Zhitao, Xu Jiaojiao, Lu Xiaojiong, Zhang Zheng
Аннотация
BACKGROUND: Recurrent myocarditis is commonly associated with infectious or immune etiologies. This case suggests a potential association between a DSP gene variant and recurrent myocarditis, highlighting a new direction for etiological investigation in such patients.
CASE PRESENTATION: We present a case of a young female admitted with chest pain and recurrent elevation of serum troponin. Cardiac magnetic resonance imaging (cMRI) revealed late gadolinium enhancement (LGE), indicating myocardial injury. No viral or other infectious causes were identified. Next-generation sequencing detected a heterozygous DSP variant (c.2297G > C, p.Ser766Thr), which was confirmed by Sanger sequencing. This finding suggests that the recurrent myocarditis may be associated with the identified DSP gene variant.
CONCLUSION: This case indicates that genetic screening should be considered in patients with recurrent myocarditis. The DSP gene should be included in relevant genetic screening panels to facilitate precise diagnosis and inform long-term management strategies.
CASE PRESENTATION: We present a case of a young female admitted with chest pain and recurrent elevation of serum troponin. Cardiac magnetic resonance imaging (cMRI) revealed late gadolinium enhancement (LGE), indicating myocardial injury. No viral or other infectious causes were identified. Next-generation sequencing detected a heterozygous DSP variant (c.2297G > C, p.Ser766Thr), which was confirmed by Sanger sequencing. This finding suggests that the recurrent myocarditis may be associated with the identified DSP gene variant.
CONCLUSION: This case indicates that genetic screening should be considered in patients with recurrent myocarditis. The DSP gene should be included in relevant genetic screening panels to facilitate precise diagnosis and inform long-term management strategies.