Octreotide Counteracts IFN-γ-Induced Endothelial Inflammation.

Endothelial cells maintain vascular homeostasis through the regulation of permeability and coagulation. Interferon-gamma (IFN-γ), a proinflammatory cytokine released by activated T lymphocytes and natural killer cells, disrupts endothelial junctional integrity, leading to barrier dysfunction. Octreotide (OCT), a synthetic somatostatin analog (SSA), is used to suppress excessive growth hormone secretion and inhibits tumor growth. The present study investigates the potential anti-inflammatory and cytoprotective properties of OCT in IFN-γ-induced endothelial injury. Our observations suggest that OCT suppresses IFN-γ-induced activation of cofilin, MLC2, JAK2, STAT1, STAT3, and P38; as well as endothelial hyperpermeability and ROS generation. Hence, the study supports ongoing efforts aiming to substantiate the protective role of somatostatin analogs in endothelium-dependent disorders, including lung injury and sepsis.