Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2026
Single-cell profiling of T/NK cell glycosylation and interaction networks during liver cirrhosis.
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Wen Chunmei, Tao Huihui, Chen Huaizhou, Pu Wenjun, Yan Qiang, Zou Yaoshuang, Zhou Lingling, Xu Tiantian, Zheng Xuejia, Wu Mengyao, Dong Qiao, Wei Lvning, Sheng Zeting, Dai Yong
Аннотация
BACKGROUND: Liver cirrhosis is a complex disease characterized by chronic inflammation and immune dysregulation, which leads to the progressive development of liver fibrosis. Glycosylation, as a critical post-translational modification, plays a pivotal role in regulating immune cell functions. However, its specific role in T/NK cells during the progression of cirrhosis remains insufficiently understood.
METHODS: This study integrates single-cell transcriptomics and glycosylation profiling to investigate changes in glycosylation-related gene expression and cellular interactions in T/NK cells from cirrhotic versus healthy liver tissues. We systematically evaluated immune cell composition, glycosylation alterations, and intercellular communication networks to elucidate the mechanisms underlying immune dysregulation in cirrhosis.
RESULTS: Significant alterations in glycosylation patterns and gene expression profiles were observed in T/NK cells from cirrhotic livers. These changes were associated with shifts in immune cell subsets and enhanced cell-cell interactions, suggesting that glycosylation modifications may play a role in modulating immune responses.
CONCLUSIONS: Our findings underscore the importance of glycosylation dynamics in the functional regulation of T/NK cells during liver cirrhosis. Targeting glycosylation pathways may offer novel therapeutic strategies to address immune imbalance and fibrosis in cirrhosis.
METHODS: This study integrates single-cell transcriptomics and glycosylation profiling to investigate changes in glycosylation-related gene expression and cellular interactions in T/NK cells from cirrhotic versus healthy liver tissues. We systematically evaluated immune cell composition, glycosylation alterations, and intercellular communication networks to elucidate the mechanisms underlying immune dysregulation in cirrhosis.
RESULTS: Significant alterations in glycosylation patterns and gene expression profiles were observed in T/NK cells from cirrhotic livers. These changes were associated with shifts in immune cell subsets and enhanced cell-cell interactions, suggesting that glycosylation modifications may play a role in modulating immune responses.
CONCLUSIONS: Our findings underscore the importance of glycosylation dynamics in the functional regulation of T/NK cells during liver cirrhosis. Targeting glycosylation pathways may offer novel therapeutic strategies to address immune imbalance and fibrosis in cirrhosis.