Journal of cataract and refractive surgery · 2000
Detection of integrins in cataract lens epithelial cells.
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Zhang X H, Ji J, Zhang H, Tang X, Sun H M, Yuan J Q
Аннотация
PURPOSE: To detect the expression of integrin subunits in lens epithelial cells (LECs) of human cataracts.
SETTING: Research Laboratory, International Intraocular Implant Training Centre, Tianjin Medical University, China.
METHODS: The circular sections of the anterior capsules with attached LECs were obtained during cataract surgery from 100 patients. The LECs were stained with an avidin-biotin-complex immunohistochemical technique using 5 monoclonal antibodies specific for alpha subunits 2, 3, 5 and beta subunits 1, 2.
RESULTS: All integrin subunits studied were found to varying degrees in specimens. The positive percentages were 70%, 65%, 75%, 70%, and 80%, respectively.
CONCLUSION: Integrin subunits were present in LECs of human cataracts. These molecules may serve in the adhesion of LECs to the lens capsule and play a role in cell-posterior capsule interaction after cataract surgery.
SETTING: Research Laboratory, International Intraocular Implant Training Centre, Tianjin Medical University, China.
METHODS: The circular sections of the anterior capsules with attached LECs were obtained during cataract surgery from 100 patients. The LECs were stained with an avidin-biotin-complex immunohistochemical technique using 5 monoclonal antibodies specific for alpha subunits 2, 3, 5 and beta subunits 1, 2.
RESULTS: All integrin subunits studied were found to varying degrees in specimens. The positive percentages were 70%, 65%, 75%, 70%, and 80%, respectively.
CONCLUSION: Integrin subunits were present in LECs of human cataracts. These molecules may serve in the adhesion of LECs to the lens capsule and play a role in cell-posterior capsule interaction after cataract surgery.