American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
Infectious disease surveillance and management in clinical xenotransplantation: Experience with the first human porcine kidney transplant.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fishman Jay A, El Khoury Joseph, Kawai Tatsuo, Riella Leonardo V, Elias Nahel, Williams Winifred, Crisalli Kerry A, Hashimoto Dean, Bercovici Sivan, Lindner Martin, Noll Nicholas, Balasundaram Gayathri, Getchell Kristen, Low Susan, Scales Brittney, Chhangawala Sagar, Marett Amanda, Curtis Michael, Yeung Vincent
Аннотация
The success and safety of clinical xenotransplantation are determined by technical aspects of surgery, the nature and intensity of immunosuppression, xenograft function, and the ability to avoid immunologic, hematologic, infectious, and malignant complications. In clinical xenotransplantation from swine, infectious challenges relate to the potential spread of pig pathogens to immunosuppressed humans as well as manifestations of infections of the recipient from prior exposures to common human organisms. Robust strategies are required for donor screening, recipient monitoring, and infection prevention. This report outlines the comprehensive infectious disease management strategy deployed in the first living human recipient of a genetically modified pig kidney, including the following: (1) donor screening and pathogen mitigation, (2) pretransplant and posttransplant infection monitoring of the recipient, (3) infectious complications and management, and (4) implications for future xenotransplantation protocols.