Comparison of the effect of isoflurane and propofol on liver regeneration after donor hepatectomy - A randomized controlled trial.

BACKGROUND

The biotransformation of inhalational anesthetic agents can result in production of hepatotoxic metabolites, which may potentially impair liver regeneration. Thus, isoflurane and propofol may have differential impacts on liver regeneration after donor hepatectomy.

STUDY

OBJECTIVE

To compare the regeneration liver volume (RgLV) via computed tomography (CT) volumetry on post-operative day (POD) 14 in isoflurane and propofol groups.

DESIGN

Randomized controlled pilot trial.

PATIENTS: Sixty donors, who underwent donor hepatectomy.

INTERVENTIONS: Patients were randomized into isoflurane and propofol group using computer generated random number tables. In isoflurane group, anesthesia was maintained with isoflurane 1-2 % in air‑oxygen mixture. In propofol group, anesthesia was maintained with the target-controlled infusion (TCI) of propofol using a TCI system (Perfusor® Space- B. Braun) at a plasma target concentration of 3-6 μg.ml-1. BIS was recorded in all patients.

MEASUREMENTS: Liver CT volumetry was assessed at POD 14.

MAIN

RESULTS

RgLV on POD14 was comparable in two groups [449.3(170) & 437.8 (177.8) cm3, [Mean Difference (MD) -11.904 95 % Confidence Interval(CI) -101.83, 78.03 respectively; p = 0.79].

CONCLUSION

Administering propofol or isoflurane may not have differential effect on liver regeneration after donor hepatectomy.