Dermatology (Basel, Switzerland) · 1999
Interleukin 11 reduces apoptosis in UVB-irradiated mouse skin.
СтатьяПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен
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Scordi I A, Nassiri M, Hanly A J, Vincek V
Аннотация
BACKGROUND: UVB radiation, the major cause of skin cancer, causes apoptosis in the skin, characterized by the appearance of 'sunburn cells'. Interleukin 11 (IL-11) has been shown to protect cells in the gastrointestinal system from chemotherapy and radiation-induced death.
OBJECTIVE: To determine whether exogenous IL-11 has any effect on the UVB-induced apoptosis of cutaneous tissues.
METHODS: Mice were injected with IL-11 or vehicle control prior to irradiation, and TUNEL assays were performed on paraffin-embedded tissue sections at various times after irradiation.
RESULTS: Exogenous IL-11 protects epidermal keratinocytes, epithelial cells of the hair follicles inflammatory cells and fibroblasts in the dermis from UVB-induced apoptotic death.
CONCLUSION: These findings suggest that IL-11 may play a role in the general homeostasis of the skin.
OBJECTIVE: To determine whether exogenous IL-11 has any effect on the UVB-induced apoptosis of cutaneous tissues.
METHODS: Mice were injected with IL-11 or vehicle control prior to irradiation, and TUNEL assays were performed on paraffin-embedded tissue sections at various times after irradiation.
RESULTS: Exogenous IL-11 protects epidermal keratinocytes, epithelial cells of the hair follicles inflammatory cells and fibroblasts in the dermis from UVB-induced apoptotic death.
CONCLUSION: These findings suggest that IL-11 may play a role in the general homeostasis of the skin.