Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2014
Transcranial Direct Current Stimulation and Cerebral Vasomotor Reserve: A Study in Healthy Subjects.
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Giorli Elisa, Tognazzi Silvia, Briscese Lucia, Bocci Tommaso, Mazzatenta Andrea, Priori Alberto, Orlandi Giovanni, Del Sette Massimo, Sartucci Ferdinando
Аннотация
BACKGROUND AND PURPOSE: Cerebral vasomotor reserve (VMR) is the capability of cerebral arterioles to change their diameter in response to various stimuli, such hypercapnia. Changes of VMR due to transcranial direct current stimulation (tDCS) have been poorly studied.
METHODS: Twenty-five healthy subjects underwent anodal/cathodal and sham tDCS on right primary motor area. Before and after tDCS, we assessed VMR by Transcranial Color-Coded Sonography (TCCS) calculating trought Breath Holding Index (BHI) and Heart Rate Variability (HRV), in particular after Valsalva manouver.
RESULTS: A-tDCS decreased VMR and BHI (p < 0.05), whereas C-tDCS increased VMR, and BHI (p < 0.05); Sham doesn't provide statistically significant of both VMR, BHI and HRV (p > 0.05).
CONCLUSIONS: Our study confirms that tDCS induces a modification of bilateral VMR with a polarity-specific effect; based on this bilateral MFV and BHI modifications, we can speculate an involvement of the SNS in the VMR regulation.
METHODS: Twenty-five healthy subjects underwent anodal/cathodal and sham tDCS on right primary motor area. Before and after tDCS, we assessed VMR by Transcranial Color-Coded Sonography (TCCS) calculating trought Breath Holding Index (BHI) and Heart Rate Variability (HRV), in particular after Valsalva manouver.
RESULTS: A-tDCS decreased VMR and BHI (p < 0.05), whereas C-tDCS increased VMR, and BHI (p < 0.05); Sham doesn't provide statistically significant of both VMR, BHI and HRV (p > 0.05).
CONCLUSIONS: Our study confirms that tDCS induces a modification of bilateral VMR with a polarity-specific effect; based on this bilateral MFV and BHI modifications, we can speculate an involvement of the SNS in the VMR regulation.
Предметные рубрики MeSH
AdultBlood Flow VelocityCerebrovascular CirculationFemaleHumansMaleMiddle AgedMiddle Cerebral ArteryMotor CortexReference ValuesReproducibility of ResultsSensitivity and SpecificityTranscranial Direct Current StimulationTreatment OutcomeUltrasonography, Doppler, TranscranialVasodilationVasomotor SystemYoung Adult