First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Ghinai Isaac, McPherson Tristan D, Hunter Jennifer C, Kirking Hannah L, Christiansen Demian, Joshi Kiran, Rubin Rachel, Morales-Estrada Shirley, Black Stephanie R, Pacilli Massimo, Fricchione Marielle J, Chugh Rashmi K, Walblay Kelly A, Ahmed N Seema, Stoecker William C, Hasan Nausheen F, Burdsall Deborah P, Reese Heather E, Wallace Megan, Wang Chen, Moeller Darcie, Korpics Jacqueline, Novosad Shannon A, Benowitz Isaac, Jacobs Max W, Dasari Vishal S, Patel Megan T, Kauerauf Judy, Charles E Matt, Ezike Ngozi O, Chu Victoria, Midgley Claire M, Rolfes Melissa A, Gerber Susan I, Lu Xiaoyan, Lindstrom Stephen, Verani Jennifer R, Layden Jennifer E, Illinois COVID-19 Investigation Team
Аннотация
METHODS: Patients with confirmed COVID-19 were defined as those with a positive SARS-CoV-2 test. Contacts were people with exposure to a patient with COVID-19 on or after the patient's symptom onset date. Contacts underwent active symptom monitoring for 14 days following their last exposure. Contacts who developed fever, cough, or shortness of breath became persons under investigation and were tested for SARS-CoV-2. A convenience sample of 32 asymptomatic health-care personnel contacts were also tested.
FINDINGS: Patient 1-a woman in her 60s-returned from China in mid-January, 2020. One week later, she was hospitalised with pneumonia and tested positive for SARS-CoV-2. Her husband (Patient 2) did not travel but had frequent close contact with his wife. He was admitted 8 days later and tested positive for SARS-CoV-2. Overall, 372 contacts of both cases were identified; 347 underwent active symptom monitoring, including 152 community contacts and 195 health-care personnel. Of monitored contacts, 43 became persons under investigation, in addition to Patient 2. These 43 persons under investigation and all 32 asymptomatic health-care personnel tested negative for SARS-CoV-2.
INTERPRETATION: Person-to-person transmission of SARS-CoV-2 occurred between two people with prolonged, unprotected exposure while Patient 1 was symptomatic. Despite active symptom monitoring and testing of symptomatic and some asymptomatic contacts, no further transmission was detected.
FUNDING: None.