Brain & spine · 2026
Mapping the healing brain: Longitudinal MRI volumetrics and outcomes across surgical techniques for primary brain abscesses.
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Harapan Biyan Nathanael, Wehn Antonia Clarissa, Herrmann Janine, Grabein Béatrice, Ringel Florian, Schmutzer-Sondergeld Michael
Аннотация
INTRODUCTION: Primary intracerebral abscesses are rare but life-threatening infections requiring prompt surgical and antibiotic treatment. Comparative outcome data on neurosurgical techniques and radiological evolution remain limited.
RESEARCH QUESTION: Do clinical outcomes and MRI-based volumetric changes differ between stereotactic aspiration, craniotomy, and burr-hole trepanation in adults and children with primary intracerebral abscesses?
MATERIAL AND METHODS: We retrospectively reviewed surgically treated patients between 2014 and 2024 at the LMU University Hospital in Munich. Abscess and perilesional edema volumes were quantified on serial MRI at clinically defined follow-up intervals. Clinical outcomes were assessed using standardized neurological and functional scales, and recurrence was further evaluated. Adult and pediatric subgroups were analyzed separately.
RESULTS: Sixty patients underwent stereotactic aspiration (53.3 %), craniotomy (36.7 %), or burr-hole trepanation (10.0 %). Mean abscess volume decreased from 18.8 cm3 preoperatively to 10.8 cm3 postoperatively, 4.4 cm3 at 4-12 weeks, and 2.2 cm3 at final follow-up. Edema volume declined from 53.4 cm3 to 35.8 cm3 postoperatively, 10.6 cm3 at 4-12 weeks, and 3.5 cm3 at last follow-up. Volume reduction patterns were similar across surgical approaches, and no significant volumetric differences were observed between pediatric and adult patients. Recurrence was unrelated to surgical modality.
DISCUSSION AND CONCLUSION: All three surgical approaches achieved substantial and sustained reductions in abscess and edema volumes, with comparable neurological outcomes across age groups. Serial MRI volumetrics provide detailed insight into the temporal evolution of intracerebral abscesses and may inform postoperative monitoring and follow-up strategies for primary brain abscesses.
RESEARCH QUESTION: Do clinical outcomes and MRI-based volumetric changes differ between stereotactic aspiration, craniotomy, and burr-hole trepanation in adults and children with primary intracerebral abscesses?
MATERIAL AND METHODS: We retrospectively reviewed surgically treated patients between 2014 and 2024 at the LMU University Hospital in Munich. Abscess and perilesional edema volumes were quantified on serial MRI at clinically defined follow-up intervals. Clinical outcomes were assessed using standardized neurological and functional scales, and recurrence was further evaluated. Adult and pediatric subgroups were analyzed separately.
RESULTS: Sixty patients underwent stereotactic aspiration (53.3 %), craniotomy (36.7 %), or burr-hole trepanation (10.0 %). Mean abscess volume decreased from 18.8 cm3 preoperatively to 10.8 cm3 postoperatively, 4.4 cm3 at 4-12 weeks, and 2.2 cm3 at final follow-up. Edema volume declined from 53.4 cm3 to 35.8 cm3 postoperatively, 10.6 cm3 at 4-12 weeks, and 3.5 cm3 at last follow-up. Volume reduction patterns were similar across surgical approaches, and no significant volumetric differences were observed between pediatric and adult patients. Recurrence was unrelated to surgical modality.
DISCUSSION AND CONCLUSION: All three surgical approaches achieved substantial and sustained reductions in abscess and edema volumes, with comparable neurological outcomes across age groups. Serial MRI volumetrics provide detailed insight into the temporal evolution of intracerebral abscesses and may inform postoperative monitoring and follow-up strategies for primary brain abscesses.