Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2010
Work-related sensitization and respiratory symptoms in carpentry apprentices exposed to wood dust and diisocyanates.
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Campo Paloma, Aranda Ana, Rondon Carmen, Doñia Inmaculada, Díaz-Perales Araceli, Canto Gabriela, Lisbona Francisco-Javier, Pineda Fernando, Blanca Miguel
Аннотация
BACKGROUND: Exposure to certain substances in the workplace may lead to sensitization and increased respiratory symptoms.
OBJECTIVE: To evaluate the frequency of work-related specific sensitization and respiratory symptoms in carpentry apprentices with occupational exposure to wood dust and diisocyanates.
METHODS: Apprentices (n=101) completed an occupational and symptoms questionnaire. Spirometry and skin prick tests to aeroallergens and to a battery of 14 different woods were performed in all the participants. Blood samples were collected for total IgE measurement and detection of specific IgE to diisocyanates.
RESULTS: Half the participants (56%) had work-related respiratory symptoms: 54% due to wood dust, 15% due diisocyanates, and 9% to both. Participants with respiratory symptoms related to wood dust exposure had a significantly lower forced expiratory volume in 1 second compared with symptomatic individuals due to diisocyanates and asymptomatic individuals (P < .05). A history of rhinitis or asthma was associated with a 2.1- or 2.8-fold increase, respectively, in the likelihood of having respiratory symptoms due to wood dust exposure. Sensitization to wood was detected in 9% of participants, all of whom were atopic with a history of rhinitis and a high total IgE level (P < .05). Sensitization to diisocyanates was detected in 2% of exposed participants.
CONCLUSIONS: Work-related respiratory symptoms are common in carpentry apprentices and are more frequently related to exposure to wood dust than to diisocyanates. Symptomatic participants due to wood dust exposure had a lower forced expiratory volume in 1 second. Individuals with a history of rhinitis or asthma had an increased risk of respiratory symptoms. Sensitization to wood was more common in atopic apprentices with a history of rhinitis and a high total IgE level.
OBJECTIVE: To evaluate the frequency of work-related specific sensitization and respiratory symptoms in carpentry apprentices with occupational exposure to wood dust and diisocyanates.
METHODS: Apprentices (n=101) completed an occupational and symptoms questionnaire. Spirometry and skin prick tests to aeroallergens and to a battery of 14 different woods were performed in all the participants. Blood samples were collected for total IgE measurement and detection of specific IgE to diisocyanates.
RESULTS: Half the participants (56%) had work-related respiratory symptoms: 54% due to wood dust, 15% due diisocyanates, and 9% to both. Participants with respiratory symptoms related to wood dust exposure had a significantly lower forced expiratory volume in 1 second compared with symptomatic individuals due to diisocyanates and asymptomatic individuals (P < .05). A history of rhinitis or asthma was associated with a 2.1- or 2.8-fold increase, respectively, in the likelihood of having respiratory symptoms due to wood dust exposure. Sensitization to wood was detected in 9% of participants, all of whom were atopic with a history of rhinitis and a high total IgE level (P < .05). Sensitization to diisocyanates was detected in 2% of exposed participants.
CONCLUSIONS: Work-related respiratory symptoms are common in carpentry apprentices and are more frequently related to exposure to wood dust than to diisocyanates. Symptomatic participants due to wood dust exposure had a lower forced expiratory volume in 1 second. Individuals with a history of rhinitis or asthma had an increased risk of respiratory symptoms. Sensitization to wood was more common in atopic apprentices with a history of rhinitis and a high total IgE level.