Respiratory investigation · 2021
Bronchiolitis obliterans after stem cell transplantation for hematologic malignancies rescued by lung transplantation: A report of two cases.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Suzuki Junya, Kasai Hajime, Terada Jiro, Shikano Kohei, Sasaki Atsushi, Suzuki Hidemi, Nakajima Takahiro, Kouchi Yusuke, Shiina Manayu, Kobayashi Takeshi, Ohwada Chikako, Ikeda Jun-Ichiro, Yoshino Ichiro, Tatsumi Koichiro
Аннотация
Bronchiolitis obliterans syndrome (BOS) occurring after hematopoietic stem cell transplantation (HSCT) for hematologic malignancies is a progressive and refractory disease, and lung transplantation (LTx) seems to be the only promising treatment. We report two cases of BOS after HSCT, which showed distinct clinical courses and were successfully treated with LTx. The respiratory symptoms and function of the two patients progressively deteriorated to a critical level during the waiting period. In one patient, recurrent and intractable pneumothoraxes consistent with thoracic air-leak syndrome (TALS) occurred, which were associated with pleuroparenchymal fibroelastosis. TALS could accelerate clinical deterioration, thus permitting a shorter waiting period for LTx.