Cancer diagnosis & prognosis · 2026
Ocular Adnexal Lymphoma: An Ophthalmologist's Perspective from a Single-center Experience.
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Pojda-Wilczek Dorota, Gerba-Górecka Karolina, Hajduga-Szewczyk Marta, Kuźbińska Aleksandra, Karska-Basta Izabella
Аннотация
BACKGROUND/AIM: Lymphomas of the orbit and orbital adnexa are important concerns in ophthalmologic practice; however, due to their nonspecific signs and symptoms, establishing a definitive diagnosis is often challenging. This study aimed to further expand understanding of these entities by assessing the histopathological subtypes and characteristic features of orbital lymphomas in a population undergoing orbital surgery at the Department of Ophthalmology in Katowice.
PATIENTS AND METHODS: Between 2011 and 2017, a total of 107 orbital surgeries were performed for various orbital tumors. Tissue samples were subjected to histopathological analysis. In all patients, orbital lesions were evaluated using contrast-enhanced magnetic resonance imaging or computed tomography. Additionally, several parameters were measured at baseline and after surgery, including best-corrected visual acuity (BCVA), intraocular pressure (IOP) and associated ocular comorbidities.
RESULTS: Histopathological examination identified B-cell lymphomas in 15 patients (8 women and 7 men; mean age, 65.61 years). Palpable orbital lesions were the most common manifestation of lymphoma (88.89% of cases). No significant changes in BCVA or intraocular pressure were observed postoperatively.
CONCLUSION: Owing to its heterogeneous nature, orbital lymphoma may present with a wide range of clinical symptoms, often mimicking inflammatory conditions. Imaging studies and histopathological examination are essential for establishing the diagnosis and guiding subsequent treatment.
PATIENTS AND METHODS: Between 2011 and 2017, a total of 107 orbital surgeries were performed for various orbital tumors. Tissue samples were subjected to histopathological analysis. In all patients, orbital lesions were evaluated using contrast-enhanced magnetic resonance imaging or computed tomography. Additionally, several parameters were measured at baseline and after surgery, including best-corrected visual acuity (BCVA), intraocular pressure (IOP) and associated ocular comorbidities.
RESULTS: Histopathological examination identified B-cell lymphomas in 15 patients (8 women and 7 men; mean age, 65.61 years). Palpable orbital lesions were the most common manifestation of lymphoma (88.89% of cases). No significant changes in BCVA or intraocular pressure were observed postoperatively.
CONCLUSION: Owing to its heterogeneous nature, orbital lymphoma may present with a wide range of clinical symptoms, often mimicking inflammatory conditions. Imaging studies and histopathological examination are essential for establishing the diagnosis and guiding subsequent treatment.