Journal of paediatrics and child health · 2025
Trends in Extreme Neonatal Hyperbilirubinaemia: A Longitudinal Population-Based Case-Control Study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Godden Beth, Woodman Richard, Morris Scott
Аннотация
AIM: To determine the incidence, causes, and clinical associations of cases of extreme neonatal hyperbilirubinaemia in South Australia.
METHODS: This was a population-based case-control study of neonates ≥ 36 weeks gestation with extreme hyperbilirubinaemia (plasma bilirubin level ≥ 450 μmol/L) in South Australia over a 12-year period, between January 2010 and December 2021. Cases of extreme hyperbilirubinaemia were detected via a state-wide pathology system. Further details were obtained using medical records. Population data from the SA Health Pregnancy Outcome Unit was used as the control group.
RESULTS: A total of 68 cases were identified. The overall incidence of extreme hyperbilirubinaemia for the 12-year period was 28.6/100 000 births, higher than a previously published Australian estimate of 9.4/100 000 live births reported over a similar period and determined by clinician reporting. Extreme hyperbilirubinaemia was associated with Asian ethnicity, ventouse delivery and early discharge. A large peak in 2020 was temporally associated with the onset of the SARS-CoV-2 pandemic.
CONCLUSIONS: The incidence of extreme hyperbilirubinaemia stayed mostly stable over 12 years in South Australia and was higher than previously described via voluntary clinician reporting. Population-based surveillance monitoring via laboratory systems is likely to be more reliable than voluntary clinician reporting. A spike in incidence in 2020 may have occurred due to pandemic-related changes in maternity and neonatal care practices.
METHODS: This was a population-based case-control study of neonates ≥ 36 weeks gestation with extreme hyperbilirubinaemia (plasma bilirubin level ≥ 450 μmol/L) in South Australia over a 12-year period, between January 2010 and December 2021. Cases of extreme hyperbilirubinaemia were detected via a state-wide pathology system. Further details were obtained using medical records. Population data from the SA Health Pregnancy Outcome Unit was used as the control group.
RESULTS: A total of 68 cases were identified. The overall incidence of extreme hyperbilirubinaemia for the 12-year period was 28.6/100 000 births, higher than a previously published Australian estimate of 9.4/100 000 live births reported over a similar period and determined by clinician reporting. Extreme hyperbilirubinaemia was associated with Asian ethnicity, ventouse delivery and early discharge. A large peak in 2020 was temporally associated with the onset of the SARS-CoV-2 pandemic.
CONCLUSIONS: The incidence of extreme hyperbilirubinaemia stayed mostly stable over 12 years in South Australia and was higher than previously described via voluntary clinician reporting. Population-based surveillance monitoring via laboratory systems is likely to be more reliable than voluntary clinician reporting. A spike in incidence in 2020 may have occurred due to pandemic-related changes in maternity and neonatal care practices.