A hybrid learning approach to better classify exhaled breath's infrared spectra: A noninvasive optical diagnosis for socially significant diseases.

Early diagnosis is crucial for effective treatment of socially significant diseases, such as type 1 diabetes mellitus (T1DM), pneumonia, and asthma. This study employs a diagnostic method based on infrared laser spectroscopy of human exhaled breath. The experimental setup comprises a quantum cascade laser, which emits in a pulsed mode with a peak power of up to 150 mW in the spectral range of 5.3-12.8 μm (780-1890 cm-1), and a Herriott multipass gas cell with a specific optical path length of 76 m. Using this setup, spectra of exhaled breath in the mid-infrared range were obtained from 165 volunteers, including healthy individuals, patients with T1DM, asthma, and pneumonia. The study proposes a hybrid approach for classifying these spectra, utilizing a variational autoencoder for dimensionality reduction and a support vector machine method for classification. The results demonstrate that the proposed hybrid approach outperforms other machine learning method combinations.