Association of genetic variations in X-ray repair cross-complementing group 1 and Tourette syndrome.

BACKGROUND

X-ray repair cross-complementing group 1 (XRCC1) plays a central role in mammalian DNA repair process. The polymorphism rs25487 (Arg>Gln at codon 399) of this gene is common in Han Chinese population.

OBJECTIVES

The objective of this study was to analyze the association between this functional SNP of XRCC1 and Tourette syndrome (TS) in Han Taiwan Chinese population.

METHODS

Genotyping was performed by using PCR-RFLP method on 73 TS patients and 158 normal controls.

RESULTS

Our data indicated that genotype frequency of A/G polymorphism at codon 399 of the patients differed from the controls (P = 0.026, OR: 2.22, 95% CI: 1.22-4.03). The allele frequency analysis also showed significant differences with higher A allele frequency in patients (P = 0.015, OR: 1.70, 95% CI: 1.11-2.62).

CONCLUSION

Our study indicates that the functional SNP at codon 399 of XRCC1 is associated with TS development.