The Journal of prosthetic dentistry · 2024
Investigating the effectiveness of atorvastatin mouthwash on denture stomatitis: A randomized, double-blind controlled trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Haghani Iman, Saeedi Majid, Babaei Amirhossein, Yahyazadeh Zahra, Hosseinnataj Abolfazl, Ebrahimi Saravi Mohammad, Akbari Fatemeh, Lotfizadeh Anahita, Rajabi Visroodi Ehsan, Molania Tahereh
Аннотация
STATEMENT OF PROBLEM: Denture stomatitis (DS) is a common oral disorder in patients with complete maxillary dentures. Typical treatments such as nystatin or azoles lead to drug resistance after a long period. Several studies have shown the antifungal activity of statins against Candida albicans; however, studies on the antifungal effect of atorvastatin against DS are lacking.
PURPOSE: The purpose of this randomized, double-blind controlled trial was to assess the effectiveness of atorvastatin mouthwash against DS.
MATERIAL AND METHODS: Twenty-two participants diagnosed with DS were randomly allocated into 2 groups: 11 in the intervention group (atorvastatin mouthwash) and 11 in the control group (nystatin). Participants were asked to use the mouthwash 3 times a day for 2 weeks. The length and width of the lesions were measured, and the number of colonies were counted on days 1 and 14. Data were analyzed with the Spearman correlation coefficient and the Mann-Whitney, Kruskal Wallis, and Wilcoxon tests (α=.05).
RESULTS: The number of colonies before and after using a mouthwash was significantly different in the control and intervention groups (P=.005 and P=.003, respectively). The number of colonies in the 2 groups were statistically similar on the first day (P=.809). However, a significant difference was observed between the groups on day 14 (P=.024). The number of colonies in the atorvastatin group decreased more than nystatin, indicating that atorvastatin was more effective. A significant difference among the groups was found in terms of Candida species detected after the intervention (P=.032).
CONCLUSIONS: Atorvastatin was effective in reducing Candida species in participants with DS and can be used as an antifungal agent in treating DS.
PURPOSE: The purpose of this randomized, double-blind controlled trial was to assess the effectiveness of atorvastatin mouthwash against DS.
MATERIAL AND METHODS: Twenty-two participants diagnosed with DS were randomly allocated into 2 groups: 11 in the intervention group (atorvastatin mouthwash) and 11 in the control group (nystatin). Participants were asked to use the mouthwash 3 times a day for 2 weeks. The length and width of the lesions were measured, and the number of colonies were counted on days 1 and 14. Data were analyzed with the Spearman correlation coefficient and the Mann-Whitney, Kruskal Wallis, and Wilcoxon tests (α=.05).
RESULTS: The number of colonies before and after using a mouthwash was significantly different in the control and intervention groups (P=.005 and P=.003, respectively). The number of colonies in the 2 groups were statistically similar on the first day (P=.809). However, a significant difference was observed between the groups on day 14 (P=.024). The number of colonies in the atorvastatin group decreased more than nystatin, indicating that atorvastatin was more effective. A significant difference among the groups was found in terms of Candida species detected after the intervention (P=.032).
CONCLUSIONS: Atorvastatin was effective in reducing Candida species in participants with DS and can be used as an antifungal agent in treating DS.