Medical journal of the Islamic Republic of Iran · 2024
Peripheral Arterial Disease is Associated with Sensorimotor Peripheral Neuropathy in People with Type 2 Diabetes.
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Hashemi-Madani Nahid, Azadi Masoumeh, Khajavi Alireza, Emami Zahra, Khamseh Mohammad E
Аннотация
BACKGROUND: Micro- and macro-vascular complications of diabetes seem to be interconnected. This study aimed to evaluate the association between peripheral arterial diseases (PAD) and diabetic sensorimotor peripheral neuropathy (DSPN).
METHODS: This cross-sectional study was conducted among 748 people with type 2 diabetes (T2DM) referred to a tertiary care center between 2017 and 2022. PAD was defined as Ankle-brachial index (ABI) ≤ 0.9. Loss of protective sensation (LOPS) was applied for the detection of DSPN. Logistic regression analysis was used to determine the association between PAD and DSPN.
RESULTS: The mean age of the participants was 59.6 (±8.8) years, and the median duration of diabetes was 10 (5-16) years. LOPS was detected in 491 individuals (65.6%). ABI ≤ 0.9 was associated with a significantly higher risk of LOPS (OR: 3.65, 95% Confidence Interval (CI): 1.97- 6.74). In addition, every 0.1 decrease in ABI increased the risk of LOPS by 21% (95%CI: 10- 34%). Toe brachial index (TBI) ≤0.7 was also associated with a significantly higher risk of LOPS (OR: 1.77, 95%CI: 1.28- 2.46). Each 0.1 decrease in TBI increased the risk of LOPS by 19% (95%CI: 10- 28%).
CONCLUSION: PAD is strongly associated with DSPN. Assessment of DSPN could be considered in the presence of PAD.
METHODS: This cross-sectional study was conducted among 748 people with type 2 diabetes (T2DM) referred to a tertiary care center between 2017 and 2022. PAD was defined as Ankle-brachial index (ABI) ≤ 0.9. Loss of protective sensation (LOPS) was applied for the detection of DSPN. Logistic regression analysis was used to determine the association between PAD and DSPN.
RESULTS: The mean age of the participants was 59.6 (±8.8) years, and the median duration of diabetes was 10 (5-16) years. LOPS was detected in 491 individuals (65.6%). ABI ≤ 0.9 was associated with a significantly higher risk of LOPS (OR: 3.65, 95% Confidence Interval (CI): 1.97- 6.74). In addition, every 0.1 decrease in ABI increased the risk of LOPS by 21% (95%CI: 10- 34%). Toe brachial index (TBI) ≤0.7 was also associated with a significantly higher risk of LOPS (OR: 1.77, 95%CI: 1.28- 2.46). Each 0.1 decrease in TBI increased the risk of LOPS by 19% (95%CI: 10- 28%).
CONCLUSION: PAD is strongly associated with DSPN. Assessment of DSPN could be considered in the presence of PAD.