Nippon Ganka Gakkai zasshi · 2008
[The ultramicrostructure of secretory granules of mast cells in giant papillae of vernal keratoconjunctivitis patients].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ebihara Nobuyuki, Watanabe Yasuo, Murakami Akira
Аннотация
PURPOSE: To investigate the subtypes, extent of activation, and method of degranulation of mast cells (MCs) by observation of the ultramicrostructure of secretory granules from MCs in the giant papillae (GP) of patients with vernal keratoconjunctivitis (VKC).
METHODS: After informed consent, 8 giant papillae were obtained from 6 patients with severe VKC during treatment. The 168 collected MCs were observed by electron microscopy.
RESULTS: Thirty-eight percent of the MCs were degranulated (17% piecemeal and 21% anaphylactic degranulation). Among the non-degranulated MCs, 13% were TC type cells containing dense amorphous granules; 9% were T type cells containing scroll granules; 15% were transient cells containing both amorphous and scroll granules; and 25% were activated MCs containing particulate granules. Three patterns (separation from the cell membrane, exocytosis, and dissolution) of granule release were recognized.
CONCLUSION: The dynamics of MCs in GP were assessed from the ultramicrostructure of the secretory granules.
METHODS: After informed consent, 8 giant papillae were obtained from 6 patients with severe VKC during treatment. The 168 collected MCs were observed by electron microscopy.
RESULTS: Thirty-eight percent of the MCs were degranulated (17% piecemeal and 21% anaphylactic degranulation). Among the non-degranulated MCs, 13% were TC type cells containing dense amorphous granules; 9% were T type cells containing scroll granules; 15% were transient cells containing both amorphous and scroll granules; and 25% were activated MCs containing particulate granules. Three patterns (separation from the cell membrane, exocytosis, and dissolution) of granule release were recognized.
CONCLUSION: The dynamics of MCs in GP were assessed from the ultramicrostructure of the secretory granules.