Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2009
Loss of maspin is a negative prognostic factor for invasion and metastasis in oral squamous cell carcinoma.
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Yoshizawa Kunio, Nozaki Shinichi, Okamune Ayako, Kitahara Hiroko, Ohara Teruhisa, Kato Koroku, Kawashiri Shuichi, Yamamoto Etsuhide
Аннотация
OBJECTIVE: Maspin, a 42-kDa protein, belongs to the serpin family of protease inhibitors and is known to have tumor-suppressor function. In this study, we investigated the interrelationship between clinicopathologic findings and maspin expression in oral squamous cell carcinoma (OSCC).
METHODS: Using immunohistochemical techniques to examine the expression levels of maspin in OSCC, maspin expression in OSCC was detected in 46 (64.8%) of 71 cases. We also compared the clonicopathologic features of OSCC cases with maspin expression levels. Moreover, we examined expression of maspin in eight cell lines derived from OSCC using reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting.
RESULTS: There was a significant correlation between decreased maspin expression and T-category (P < 0.01), lymph metastasis (P < 0.0001), and mode of invasion (P < 0.0001). Patients with positive maspin expression had a significantly better prognosis (P < 0.001). Lower expression of maspin was also seen in cell lines derived from grade 4D, which shows stronger invasive potential than other grades of OSCC.
CONCLUSION: Maspin may be a useful marker to identify the potential for progression in OSCC.
METHODS: Using immunohistochemical techniques to examine the expression levels of maspin in OSCC, maspin expression in OSCC was detected in 46 (64.8%) of 71 cases. We also compared the clonicopathologic features of OSCC cases with maspin expression levels. Moreover, we examined expression of maspin in eight cell lines derived from OSCC using reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting.
RESULTS: There was a significant correlation between decreased maspin expression and T-category (P < 0.01), lymph metastasis (P < 0.0001), and mode of invasion (P < 0.0001). Patients with positive maspin expression had a significantly better prognosis (P < 0.001). Lower expression of maspin was also seen in cell lines derived from grade 4D, which shows stronger invasive potential than other grades of OSCC.
CONCLUSION: Maspin may be a useful marker to identify the potential for progression in OSCC.
Предметные рубрики MeSH
AdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Squamous CellCell Line, TumorDisease ProgressionFemaleFollow-Up StudiesGingival NeoplasmsHumansLymphatic MetastasisMaleMiddle AgedMouth NeoplasmsNeoplasm InvasivenessNeoplasm StagingPrognosisSerine Proteinase InhibitorsSerpinsSurvival RateTongue NeoplasmsTumor Suppressor Proteins