The Journal of sports medicine and physical fitness · 2025
Initial and evolutionary profile of adverse responders to an intensive weight loss intervention: the RESOLVE Study.
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Bailly Mélina, Isacco Laurie, Dutheil Frédéric, Courteix Daniel, Lesourd Bruno, Chapier Robert, Obert Philippe, Walther Guillaume, Bagheri Réha, Vinet Agnes, Metz Lore, Verney Julien, Ennequin Gael, Drapeau Vicky, Pereira Bruno, Thivel David, Tremblay Angelo
Аннотация
BACKGROUND: There is a need to better identify adverse responders to weight-loss interventions. The aim of this study was to: 1) identify potential predictive factors of adverse responders to weight loss; and 2) follow their long-term evolution.
METHODS: One-hundred participants (56 females) with overweight (59.5±4.9 years) followed a 3-week intervention combining physical activity and diet followed by one-year monitoring, and were divided into three subgroups: 1) group A (N.=13) - "regainers" (weight regain during follow-up >100% of initial loss); 2) group B (N.=25) - "moderate regainers" (weight regain: 0-100%); and 3) group C (N.=46) - "weight relosers" (weight regain <0%). Body composition, food consumption, inflammatory and metabolic markers were assessed during the intervention and follow-up.
RESULTS: Baseline energy intake was lower in group A(1518±361kcal/day) vs. group B (1929±451kcal/day) (P=0.013) and C(1882±572kcal/day) (P=0.024). Group A initially presented a healthier metabolic profile and the total score of compliance (diet + physical activity) was lower in group A during follow-up (group A:38.3% vs. B:49.2%(P=0.007) and C:72.1% (P<0.001). Ghrelin levels tend to decrease and peptide YY (PYY) to increase during follow-up in groups B and C while blunted responses were obtained in A.
CONCLUSIONS: Adverse responders might be characterized by a less unhealthy metabolic profile at baseline but also by less favorable changes in their satiety-regulating hormones during the one-year follow-up.
METHODS: One-hundred participants (56 females) with overweight (59.5±4.9 years) followed a 3-week intervention combining physical activity and diet followed by one-year monitoring, and were divided into three subgroups: 1) group A (N.=13) - "regainers" (weight regain during follow-up >100% of initial loss); 2) group B (N.=25) - "moderate regainers" (weight regain: 0-100%); and 3) group C (N.=46) - "weight relosers" (weight regain <0%). Body composition, food consumption, inflammatory and metabolic markers were assessed during the intervention and follow-up.
RESULTS: Baseline energy intake was lower in group A(1518±361kcal/day) vs. group B (1929±451kcal/day) (P=0.013) and C(1882±572kcal/day) (P=0.024). Group A initially presented a healthier metabolic profile and the total score of compliance (diet + physical activity) was lower in group A during follow-up (group A:38.3% vs. B:49.2%(P=0.007) and C:72.1% (P<0.001). Ghrelin levels tend to decrease and peptide YY (PYY) to increase during follow-up in groups B and C while blunted responses were obtained in A.
CONCLUSIONS: Adverse responders might be characterized by a less unhealthy metabolic profile at baseline but also by less favorable changes in their satiety-regulating hormones during the one-year follow-up.