Synthesis of furochromene derivatives employing multicomponent reactions and SiO2/Fe3O4 as a nanomagnetic catalyst: study of biological activity and reduction of organic pollutants.

In this research, furochromene derivatives were synthesized using multicomponent reactions of dihydroxyacetophenone, isopropenylacetylene, aldehydes and 1,3-dicarbonyl compounds in aqueous media at room temperature in the presence of bio-Fe3O4/SiO2 magnetic nanoparticles (MNPs). The catalytic activity of the bio-Fe3O4/SiO2 was evaluated in the reduction of organic pollutants such as 4-nitrophenol (4-NP) in water under mild conditions. The results indicated that the biosynthesized Fe3O4/SiO2 MNPs exhibited high catalytic activity, enabling the removal of organic pollutants within a few seconds. To determine the antioxidant activity of the synthesized furochromenes, diphenylpicrylhydrazine (DPPH) radical scavenging assays were applied. A further evaluation of the antibacterial activity of the generated compounds was carried out in a methodical manner by employing the disk diffusion technique using two distinct strains of Gram-negative bacteria as well as Gram-positive bacteria. The synthesis approach that was applied for the development of furochromenes was marked by a confluence of good properties. One of these characteristics was the ability to recover the catalyst from the reaction environment with an external magnet. Other characteristics included faster reaction kinetics and greater product yields.