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Войти в исследования Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2010
Using retinal architecture to help characterize multiple sclerosis patients.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Costello Fiona, Hodge William, Pan Y Irene, Eggenberger Eric, Freedman Mark S
Аннотация
OBJECTIVE: We compared retinal nerve fibre layer (RNFL) thickness and visual function in a heterogeneous multiple sclerosis (MS) cohort to determine whether optical coherence tomography (OCT) may complement the existing methods used to characterize MS patients.
DESIGN: Cross-sectional cohort study.
PARTICIPANTS: One hundred and ninety-three patients with optic neuritis (ON) as a clinically isolated syndrome (CIS) (n = 63), relapsing-remitting MS (RRMS) (n = 108), secondary progressive MS (SPMS) (n = 13), and primary progressive MS (PPMS) (n = 9).
METHODS: All patients underwent standardized ophthalmic, neurological, and OCT testing at a single academic institution.
RESULTS: RNFL values were reduced in PPMS (94.3 µm), RRMS (99.6 µm), and SPMS eyes (84.7 µm) relative to CIS eyes (105.7 µm) (p<0.0001). RNFL values were lower in eyes with recurrent ON (64.2 µm) relative to eyes affected by a single ON event (86.3 µm) (p<0.0001). The strongest correlation between RNFL thickness and neurological disability occurred in RRMS patients (r = -0.51, p < 0.0001). RNFL thickness correlated with visual field sensitivity for CIS (r = 0.23, p < 0.01) and RRMS (r = 0.22, p < 0.01) patients. Simple linear regression showed that every 10 µm decrease in RNFL correlated with a 5.8 decibel decrease in visual field sensitivity (adjusted R2 = 0.35, p < 0.0001) for RNFL values less than 75 µm.
CONCLUSIONS: There were robust correlations between RNFL thickness and visual function, particularly in ON eyes. OCT may complement the existing tools used to characterize MS patients, but further studies are needed.
DESIGN: Cross-sectional cohort study.
PARTICIPANTS: One hundred and ninety-three patients with optic neuritis (ON) as a clinically isolated syndrome (CIS) (n = 63), relapsing-remitting MS (RRMS) (n = 108), secondary progressive MS (SPMS) (n = 13), and primary progressive MS (PPMS) (n = 9).
METHODS: All patients underwent standardized ophthalmic, neurological, and OCT testing at a single academic institution.
RESULTS: RNFL values were reduced in PPMS (94.3 µm), RRMS (99.6 µm), and SPMS eyes (84.7 µm) relative to CIS eyes (105.7 µm) (p<0.0001). RNFL values were lower in eyes with recurrent ON (64.2 µm) relative to eyes affected by a single ON event (86.3 µm) (p<0.0001). The strongest correlation between RNFL thickness and neurological disability occurred in RRMS patients (r = -0.51, p < 0.0001). RNFL thickness correlated with visual field sensitivity for CIS (r = 0.23, p < 0.01) and RRMS (r = 0.22, p < 0.01) patients. Simple linear regression showed that every 10 µm decrease in RNFL correlated with a 5.8 decibel decrease in visual field sensitivity (adjusted R2 = 0.35, p < 0.0001) for RNFL values less than 75 µm.
CONCLUSIONS: There were robust correlations between RNFL thickness and visual function, particularly in ON eyes. OCT may complement the existing tools used to characterize MS patients, but further studies are needed.