An attempt at conservative treatment in selected cases of type I endometrial carcinoma (stage I a/G1) in young women.

PURPOSE: The aim of the study was to evaluate an attempt of conservative treatment in selected cases of endometrial carcinoma Stage I A/type I in young women.

MATERIALS AND

METHODS

The study comprised five young nulliparous women aged 24-38 (30.8 +/- 4.2) with well-defined type I endometrial carcinoma Stage I A/G1. Diagnostic dilatation and curettage (D&C) in these women was performed. Biochemical hormonal studies comprised the assessment of estrone, estradiol, progesterone, prolactin in basal conditions, prolactin after a metoclopramide test and total testosterone. In the treatment phase estriol was given intravaginally. Additionally progesterone was applied for 12 days in the second phase of therapeutic cycles. Moreover the women were given ergocryptine and metformin.

RESULTS

After six months of therapy and during two years of follow-up histopathological examinations of material obtained from D&C the endometrial pattern was normal and free of cancer cells.

CONCLUSIONS

1) In selected cases the conservative treatment of young women diagnosed with type I endometrial carcinoma Stage I A/G1 could be indicated. 2) Conservative pharmacological treatment of young women with well-defined endometrial carcinoma Stage I A/G1 type I should be monitored with followup histopathological examinations of material obtained from D&C of the endometrium and assessment of concentrations of sex hormones in the serum. 3) This kind of therapy requires frequent and thorough gynecological and clinical follow-up.