Standardized echography in uveal melanomas with scleral or extraocular extension.

Three cases of uveal melanoma with scleral or extraocular extension as detected by standardized echography and confirmed histopathologically are reported. Two patients had scleral and orbital extension: one patient had a huge intraocular tumor and small orbital nodule, while the other had a small intraocular tumor with massive orbital involvement. In the third patient, early scleral extension (less than 25% of its thickness) was detected echographically. The early detection of scleral or extraocular extension, which are known poor prognostic factors, should be routinely attempted with standardized echography even in a small, apparently stable uveal melanoma.