Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ-Global Registry for Emerging Fungal Infections.
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Salmanton-García Jon, Koehler Philipp, Kindo Anupma, Falces-Romero Iker, García-Rodríguez Julio, Ráčil Zdeněk, Chen Sharon C-A, Klimko Nikolai, Desoubeaux Guillaume, Thompson George R, Benítez-Peñuela Miguel-Ángel, Rodríguez José-Yesid, Sheppard Donald C, Hoenigl Martin, Le Govic Yohann, Badali Hamid, Baddley John W, Chander Jagdish, Ingram Paul R, Pakstis Diana L, Mellinghoff Sibylle C, Atıcı Serkan, Cesaro Simone, Chakrabarti Arunaloke, Dupont Damien, González Gloria M, Hatvani Lóránt, Herbrecht Raoul, Klyasova Galina, Lass-Flörl Cornelia, Mareș Mihai, Mullane Kathleen, Vinh Donald C, Wisplinghoff Hilmar, Lackner Michaela, Cornely Oliver A, Seidel Danila, ECMM/ISHAM working group
Аннотация
METHODS: Extremely rare IFI collected in the FungiScopeⓇ registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales.
RESULTS: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScopeⓇ. Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales.
CONCLUSIONS: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens.