Causal relationship between inflammatory skin diseases and immunoglobulin A nephropathy: A Mendelian randomization and enrichment analysis study.

OBJECTIVE

To investigate the causal relationship between inflammatory skin diseases (atopic dermatitis, and psoriasis) and IgA nephropathy using Mendelian randomization and enrichment analysis.

METHODS

The instrumental variables (IVs) in the European Bioinformatics Institute (EBI) database were used for two-sample MR analysis. The results of inverse variance weighting (IVW) were used as the main method, the MR-Egger method was used for pleiotropy analysis and the leave-one-out method was used for sensitivity analysis to verify the reliability of the data. Combined with the human genome database GeneCards database and Metascape enrichment analysis.

RESULTS

People with AD had an increased risk of IgA nephropathy (IVW: OR = 1.06, 95% CI [1.0002-1.1248], p = 0.0491). Psoriasis and IgA nephropathy (IVW: OR = 0.97, 95% CI [0.9394-1.0055], p = 0.1002) no statistical significance, therefore cannot prove cause-and-effect relationship between.

CONCLUSIONS

This study provides evidence that atopic dermatitis is associated with an increased risk of IgA nephropathy, but does not provide evidence that psoriasis is causologically associated with IgA nephropathy. Enrichment analysis suggested a causal relationship between inflammatory skin diseases and IgA nephropathy at the genetic level.