Journal of veterinary internal medicine · 2026
Pharmacokinetic analysis and steady-state predictions of different preparations of metronidazole administered per rectum in adult horses.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Auvinen Jenni R E, Kritchevsky Janice E, Reinhart Jennifer M, Gochenauer Alexandria E, Jannasch Amber S, Han-Hallett Yu
Аннотация
BACKGROUND: Manipulation of forms of rectally administered metronidazole to improve bioavailability in horses has not been reported.
HYPOTHESIS/OBJECTIVES: Evaluate the pharmacokinetics of 3 rectal metronidazole preparations compared to nasogastric (NG) administration.
ANIMALS: Seven healthy horses.
METHODS: Phase 1A was a randomized, 3-way crossover, single-dose pharmacokinetic study, and Phases 1B and 2 were non-randomized, single-dose follow-up studies. Metronidazole (20 mg/kg) was administered NG and rectally in water (RW20), as a rectal gel (RG), and in dimethyl sulfoxide (DMSO). Metronidazole (80 mg/kg) was also administered rectally in water (RW80) to 3 horses. Plasma concentrations were measured using liquid chromatography/tandem mass spectrometry. Pharmacokinetic variables were calculated, and predicted steady-state area under the curve (AUC0-24,ss) to minimum inhibitory concentration ratio was used as a pharmacodynamic target.
RESULTS: Bioavailabilities for RW20 (33.7%), RG (2.49%), and DMSO (12.0%) were low relative to NG administration. When administered at a dosage of 20 mg/kg, only NG every 8 h was predicted to achieve the pharmacodynamic target in all horses. Administered rectally in water, the metronidazole maximum concentration increased from 3.11 +/- 0.63 μg/mL to 4.19 +/- 1.04 μg/mL when the dose was increased to 80 mg/kg. The RW80 predicted AUC0-24,ss for every 8 h administration was above target for all 3 horses.
CONCLUSIONS AND CLINICAL IMPORTANCE: With the tested preparations, rectal administration of metronidazole at a standard dosage of 20 mg/kg yielded subtherapeutic plasma concentrations. Administering a 4-fold higher dose rectally in water might overcome these limitations. Oral and intravenous routes remain the preferred methods for administering metronidazole in horses.
HYPOTHESIS/OBJECTIVES: Evaluate the pharmacokinetics of 3 rectal metronidazole preparations compared to nasogastric (NG) administration.
ANIMALS: Seven healthy horses.
METHODS: Phase 1A was a randomized, 3-way crossover, single-dose pharmacokinetic study, and Phases 1B and 2 were non-randomized, single-dose follow-up studies. Metronidazole (20 mg/kg) was administered NG and rectally in water (RW20), as a rectal gel (RG), and in dimethyl sulfoxide (DMSO). Metronidazole (80 mg/kg) was also administered rectally in water (RW80) to 3 horses. Plasma concentrations were measured using liquid chromatography/tandem mass spectrometry. Pharmacokinetic variables were calculated, and predicted steady-state area under the curve (AUC0-24,ss) to minimum inhibitory concentration ratio was used as a pharmacodynamic target.
RESULTS: Bioavailabilities for RW20 (33.7%), RG (2.49%), and DMSO (12.0%) were low relative to NG administration. When administered at a dosage of 20 mg/kg, only NG every 8 h was predicted to achieve the pharmacodynamic target in all horses. Administered rectally in water, the metronidazole maximum concentration increased from 3.11 +/- 0.63 μg/mL to 4.19 +/- 1.04 μg/mL when the dose was increased to 80 mg/kg. The RW80 predicted AUC0-24,ss for every 8 h administration was above target for all 3 horses.
CONCLUSIONS AND CLINICAL IMPORTANCE: With the tested preparations, rectal administration of metronidazole at a standard dosage of 20 mg/kg yielded subtherapeutic plasma concentrations. Administering a 4-fold higher dose rectally in water might overcome these limitations. Oral and intravenous routes remain the preferred methods for administering metronidazole in horses.