COVID-19: concern about interrupting social isolation of healthcare workers and professionals. What should be done with the results of the available COVID-19 diagnostic tests?
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Calabrese Laura, Cartocci Alessandra, Vitale Antonio, Martín-Nares Eduardo, D'Onghia Martina, Caggiano Valeria, Torres-Ruiz Jiram, Lopez Roberta, Jahnz-Rozyk Karina, Rybak Katarzyna, Frassi Micol, Franceschini Franco, Crisafulli Francesca, Tufan Abdurrahman, Kucuk Hamit, Avanoglu Guler Aslihan, Gidaro Antonio, La Cava Leyla, Della Casa Francesca, Mormile Ilaria, Cinotti Elisa, Lopalco Giuseppe, Sota Jurgen, Sbalchiero Jessica, Emmi Giacomo, Recke Andreas, Costi Stefania, Sfriso Paolo, Monti Sara, Viapiana Ombretta, Hinojosa-Azaola Andrea, Balistreri Alberto, Fabiani Claudia, Frediani Bruno, Rubegni Pietro, Wiesik-Szewczyk Ewa, Cantarini Luca
Аннотация
METHODS: We review our data on circulation levels of NGF in allergic diseases as well as on the relationships between this neurotrophin and primary and secondary effector cells of allergic inflammation.
RESULTS: In vernal keratoconjunctivitis, a close relationship exists between the increased NGF plasma values and the number of mast cells infiltrating the conjunctiva. NGF serum values are also increased in other allergic diseases and asthma, and are related to the severity of the inflammatory process and disease. Human CD4+ T cell clones (preferentially of activated Th2 type) produce and release NGF, and express high-affinity NGF receptors. NGF is preformed in and can act on human peripheral blood eosinophils to preferentially release inflammatory mediators. Immunoreactivity for high affinity NGF receptors is present both in basal epithelial cells and in the inflamed stroma of the allergic conjunctiva. Topical administration of NGF results in a complete healing of neurotophic corneal ulcers in man, thus suggesting a profound effect of NGF on human fibroblasts and extracellular matrix.
CONCLUSION: Data presented suggest that NGF is an important molecule in allergic inflammation and tissue remodelling occurring in allergic diseases.