Diagnostic microbiology and infectious disease · 2018
Depression of lymphocyte activity during cutaneous leishmaniasis: a case report.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Matera Giovanni, Torti Carlo, Mazzitelli Maria, Greco Giuseppe, Rania Antonella, Peronace Cinzia, Settembre Pio, Galati Luisa, Giancotti Aida, Lamberti Angelo G, Barreca Giorgio S, Rossi Marco, Quirino Angela, Liberto Maria Carla, Focà Alfredo
Аннотация
Skin leishmaniasis includes lesions of different appearance, shape, and severity, spanning from alarming diffuse lesions to an asymptomatic course. Moreover, aspecific presentation, as well as challenging differential diagnosis of cutaneous leishmaniasis, may request more in-depth investigations on the intriguing and complex pathogenesis of such infection. A 7-year case of worsening cutaneous leishmaniasis in the left frontoparietal region of the scalp, achieving omolateral eyebrow, in a 68-year-old male patient prompted us to address the immunity profile of peripheral blood lymphocytes. An increase of regulatory CD19+/CD38bright/CD24bright B cell lymphocytes was observed at the front of normal levels of other lymphocytes subpopulations, including CD4+/CD25bright T cells. The total IgG and IgM, as well as proinflammatory subclasses of IgG, were below the normal range. However, IgG4 subclass was found normal. In conclusion, our data may indicate inhibition of humoral immunity associated with an increase of lymphocyte B-regulatory subpopulation.