[Gastrin secretion during food stimulation in digestive system diseases].

The effect of food on gastrin secretion was examined in 62 patients with various diseases of the alimentary system (chronic gastritis, chronic cholecystitis, chronic pancreatitis) and in 16 normal subjects. In normal persons, the initial gastrin level in the blood was 55.4 +/- 5.2 ng/ml, while in patients with chronic gastritis and chronic pancreatitis, it was increased and in chronic cholecystitis diminished. Development of atrophic gastritis led to the delay of gastrin secretion irrespective of the food irritant type. The patients suffering from chronic cholecystitis manifested a paradoxical reaction (a decrease in gastrin concentration) to fat intake. The patients with chronic pancreatitis showed a decrease in the gastrin content in response to glucose and absence of substantial changes in response to fat.