Adipose derived stem cells to construct parathyroid organoid for hypoparathyroidism.

Hypoparathyroidism is one of the most common postoperative complications of thyroid surgery, and organoid transplantation is a frontier field expected to treat hypoparathyroidism. Organoids are three-dimensional cell aggregates derived from embryonic stem cells, pluripotent stem cells, or tissue precursor cells, possessing similar structures and functions to organs. Thus they can replace diseased organs to play a role. Adipose-derived stem cells (ASCs) are a population of postnatal stem cells residing in the fat tissue, capable of differentiating into parathyroid-like cells with parathyroid hormone secretion function. Additionally, we have prepared cartilaginous organoids by intelligent porous hydrogel and differentiated ASCs via "bottom-up" strategy in vitro. Therefore, we speculate that parathyroid organoids can be achieved by the biomaterial-assisted assembly of differentiated adipose stem cells and it is a promising treatment for hypoparathyroidism.