Longitudinal outcomes of iStent inject with cataract surgery compared with cataract surgery alone: real-world data from the Fight Glaucoma Blindness registry.

PURPOSE: To compare combined phacoemulsification and iStent inject with phacoemulsification alone.

SETTING

Fight Glaucoma Blindness (FGB) registry, Sydney, Australia.

DESIGN

Prospective observational registry study.

METHODS

Eyes that had combined phacoemulsification with iStent inject (iStent group), n = 1257 were compared with eyes that had phacoemulsification only (cataract alone, n = 163). The primary outcome was percentage of eyes achieving >20% intraocular pressure (IOP) reduction from baseline 12 months postoperatively. Secondary outcomes included mean IOP and medication reduction, adverse events, and secondary procedures.

RESULTS

At 12 months, the percentage of eyes achieving >20% reduction of IOP was significantly higher in the iStent group compared with the cataract-alone group (40.9% vs 30.1% P < .001). Adverse events occurred at a low rate in both groups, and secondary IOP-lowering procedures were significantly less frequent in the iStent group compared with cataract alone.

CONCLUSIONS

Real-world outcomes from the FGB registry at 12 months show that phacoemulsification combined with iStent inject has a higher efficacy and reduced need for secondary IOP-lowering surgery compared with phacoemulsification alone.