Hemoadsorption Therapy for Calcium Channel Blocker Overdose at a Tertiary-level Intensive Care Unit: A Retrospective Study.

OBJECTIVE

To describe the burden of calcium channel blocker (CCB) overdose at a tertiary intensive care unit (ICU).

DESIGN AND

SETTING

Retrospective study of patients admitted to the ICU with CCB overdose from 2020 to 2022.

PARTICIPANTS

Adult participants with clinically confirmed CCB overdose.

MAIN OUTCOME: Admission frequency, management strategies, and patient outcomes.

RESULTS

A total of 1719 ICU admissions over the study period, 24 (1.4%) had CCB overdose with a case fatality rate of 12.5% (3/24). Interventions included mechanical ventilation (MV) (71%), vasopressors (92%), high-dose insulin euglycemic therapy (HIET) (71%), calcium (42%), methylene blue (4%), and fluid therapy (100%). Thirteen patients (54%) received hemoadsorption therapy (HA), and eleven received standard of care (SoC) based on current guidelines. The resin hemoadsorption group had a higher SAPS II score (p = 0.002), and a greater total maximal vasopressor dose (p = 0.001) than SoC group. The HA group also had a lower admission mean arterial pressure (MAP), (p = 0.014), a greater MAP increase at 48 hours (p = 0.044), and a longer ICU length of stay (LOS) (p = 0.004) compared to the SoC group. There was one death in the HA group (7.7%) and two in the SoC group (18.2%).

CONCLUSION

Calcium channel blocker overdose is an important and life-threatening cause of toxicology admissions in the ICU. Modern resin HA may contribute to improved hemodynamic stability providing a safe and important rescue therapy in cases with refractory shock. Well-designed studies are required to confirm its role in enhancing drug clearance thereby improving the hemodynamic state and clinical outcomes.

HOW TO CITE THIS ARTICLE: Omar S, Shukla V, Khan AB, Dangor Z. Hemoadsorption Therapy for Calcium Channel Blocker Overdose at a Tertiary-level Intensive Care Unit: A Retrospective Study. Indian J Crit Care Med 2025;29(2):130-136.