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DOI 10.1038/s41467-020-19733-6

Медицинская библиотека · Nature communications · 2020

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.

Steinthorsdottir Valgerdur, McGinnis Ralph, Williams Nicholas O, Stefansdottir Lilja, Thorleifsson Gudmar, Shooter Scott, Fadista João, Sigurdsson Jon K, Auro Kirsi M, Berezina Galina, Borges Maria-Carolina, Bumpstead Suzannah, Bybjerg-Grauholm Jonas, Colgiu Irina, Dolby Vivien A, Dudbridge Frank, Engel Stephanie M, Franklin Christopher S, Frigge Michael L, Frisbaek Yr, Geirsson Reynir T, Geller Frank, Gretarsdottir Solveig, Gudbjartsson Daniel F, Harmon Quaker, Hougaard David Michael, Hegay Tatyana, Helgadottir Anna, Hjartardottir Sigrun, Jääskeläinen Tiina, Johannsdottir Hrefna, Jonsdottir Ingileif, Juliusdottir Thorhildur, Kalsheker Noor, Kasimov Abdumadjit, Kemp John P, Kivinen Katja, Klungsøyr Kari, Lee Wai K, Melbye Mads, Miedzybrodska Zosia, Moffett Ashley, Najmutdinova Dilbar, Nishanova Firuza, Olafsdottir Thorunn, Perola Markus, Pipkin Fiona Broughton, Poston Lucilla, Prescott Gordon, Saevarsdottir Saedis, Salimbayeva Damilya, Scaife Paula Juliet, Skotte Line, Staines-Urias Eleonora, Stefansson Olafur A, Sørensen Karina Meden, Thomsen Liv Cecilie Vestrheim, Tragante Vinicius, Trogstad Lill, Simpson Nigel A B, FINNPEC Consortium, GOPEC Consortium, Aripova Tamara, Casas Juan P, Dominiczak Anna F, Walker James J, Thorsteinsdottir Unnur, Iversen Ann-Charlotte, Feenstra Bjarke, Lawlor Deborah A, Boyd Heather Allison, Magnus Per, Laivuori Hannele, Zakhidova Nodira, Svyatova Gulnara, Stefansson Kari, Morgan Linda

СтатьяМетаанализПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.

Для цитирования: Steinthorsdottir Valgerdur, McGinnis Ralph, Williams Nicholas O, Stefansdottir Lilja, Thorleifsson Gudmar, Shooter Scott, Fadista João, Sigurdsson Jon K, Auro Kirsi M, Berezina Galina, Borges Maria-Carolina, Bumpstead Suzannah, Bybjerg-Grauholm Jonas, Colgiu Irina, Dolby Vivien A, Dudbridge Frank, Engel Stephanie M, Franklin Christopher S, Frigge Michael L, Frisbaek Yr, Geirsson Reynir T, Geller Frank, Gretarsdottir Solveig, Gudbjartsson Daniel F, Harmon Quaker, Hougaard David Michael, Hegay Tatyana, Helgadottir Anna, Hjartardottir Sigrun, Jääskeläinen Tiina, Johannsdottir Hrefna, Jonsdottir Ingileif, Juliusdottir Thorhildur, Kalsheker Noor, Kasimov Abdumadjit, Kemp John P, Kivinen Katja, Klungsøyr Kari, Lee Wai K, Melbye Mads, Miedzybrodska Zosia, Moffett Ashley, Najmutdinova Dilbar, Nishanova Firuza, Olafsdottir Thorunn, Perola Markus, Pipkin Fiona Broughton, Poston Lucilla, Prescott Gordon, Saevarsdottir Saedis, Salimbayeva Damilya, Scaife Paula Juliet, Skotte Line, Staines-Urias Eleonora, Stefansson Olafur A, Sørensen Karina Meden, Thomsen Liv Cecilie Vestrheim, Tragante Vinicius, Trogstad Lill, Simpson Nigel A B, FINNPEC Consortium, GOPEC Consortium, Aripova Tamara, Casas Juan P, Dominiczak Anna F, Walker James J, Thorsteinsdottir Unnur, Iversen Ann-Charlotte, Feenstra Bjarke, Lawlor Deborah A, Boyd Heather Allison, Magnus Per, Laivuori Hannele, Zakhidova Nodira, Svyatova Gulnara, Stefansson Kari, Morgan Linda. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.. Nature communications. 2020. DOI: 10.1038/s41467-020-19733-6.

Предметные рубрики MeSH

Adaptor Proteins, Signal TransducingAdultAgedAlpha-Ketoglutarate-Dependent Dioxygenase FTOAsia, CentralBlood PressureCase-Control StudiesDatasets as TopicEuropeFemaleFibroblast Growth Factor 5Genetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansHypertension, Pregnancy-InducedMDS1 and EVI1 Complex Locus ProteinMiddle AgedMultifactorial InheritancePre-EclampsiaPregnancyProspective Studies
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