Biophotonics discovery · 2025
In vivo fundus imaging and computational refocusing with a diffuser-based fundus camera.
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Simmerer Corey, Morakis Marisa, Tian Lei, Gomez-Perez Lia, Liu T Y Alvin, Durr Nicholas J
Аннотация
SIGNIFICANCE: Access to diagnostic eye care could be expanded with high-throughput and easy-to-use tools. Phase mask-based imaging may improve the fundus camera by enabling computational refocusing with no moving parts, reducing hardware complexity and cost. Although phase mask-based imaging has been demonstrated in a model eye, this approach has not been shown in vivo.
AIM: A computational fundus camera was designed, constructed, and evaluated with the goal of determining the feasibility and performance of phase mask-based computational imaging of the in vivo fundus.
APPROACH: A holographic diffuser was introduced in a modified commercial fundus camera at a plane conjugate to the ocular pupil, resulting in a linear and shift-invariant point spread function that varies with refractive error. The image could be digitally refocused across a range of ≥ ± 10 diopters of defocus error. The device was tested for ocular safety, and a human imaging pilot study was performed.
RESULTS: The device captured and digitally refocused color human fundus images. The field of view was ≥ 35 deg , and resolution was 7.7 to 9.6 line pairs per millimeter.
CONCLUSION: We present the first in vivo diffuser-based fundus images, demonstrating the feasibility of computational imaging for ocular diagnostics.
AIM: A computational fundus camera was designed, constructed, and evaluated with the goal of determining the feasibility and performance of phase mask-based computational imaging of the in vivo fundus.
APPROACH: A holographic diffuser was introduced in a modified commercial fundus camera at a plane conjugate to the ocular pupil, resulting in a linear and shift-invariant point spread function that varies with refractive error. The image could be digitally refocused across a range of ≥ ± 10 diopters of defocus error. The device was tested for ocular safety, and a human imaging pilot study was performed.
RESULTS: The device captured and digitally refocused color human fundus images. The field of view was ≥ 35 deg , and resolution was 7.7 to 9.6 line pairs per millimeter.
CONCLUSION: We present the first in vivo diffuser-based fundus images, demonstrating the feasibility of computational imaging for ocular diagnostics.