Alcohol and alcoholism (Oxford, Oxfordshire) · 2014
Utilization of baclofen in maintenance of alcohol abstinence in patients with alcohol dependence and alcoholic hepatitis with or without cirrhosis.
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Yamini David, Lee Scott Hyunsoo, Avanesyan Armine, Walter Michael, Runyon Bruce
Аннотация
AIM: To report the efficacy and safety of baclofen in improving clinical state in patients with alcoholic hepatitis.
METHOD: Single center, open, retrospective study analyzing the effects of baclofen utilized over 12 months in patients with alcoholic hepatitis with or without cirrhosis and alcohol dependence on these liver parameters: aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (Tbili), prothrombin time (PT), international normalized ratio (INR), albumin and Model for End-Stage Liver Disease (MELD) score.
RESULTS: Out of 40 patients, 35 were treated with baclofen. On average, baclofen was used for 5.8 months. A significant decrease in the mean AST, ALT, Tbili, INR, PT and MELD score was seen when comparing pre-baclofen use compared with post-baclofen use. Of the 35 patients who were started on baclofen, 34 (97%) remained abstinent. There were no serious adverse events.
CONCLUSIONS: Baclofen's safety and efficacy in improving the clinical condition patients with alcoholic liver disease has been supported. Randomized prospective studies with longer duration of baclofen in this population may further optimize its use and corroborate efficacy.
METHOD: Single center, open, retrospective study analyzing the effects of baclofen utilized over 12 months in patients with alcoholic hepatitis with or without cirrhosis and alcohol dependence on these liver parameters: aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (Tbili), prothrombin time (PT), international normalized ratio (INR), albumin and Model for End-Stage Liver Disease (MELD) score.
RESULTS: Out of 40 patients, 35 were treated with baclofen. On average, baclofen was used for 5.8 months. A significant decrease in the mean AST, ALT, Tbili, INR, PT and MELD score was seen when comparing pre-baclofen use compared with post-baclofen use. Of the 35 patients who were started on baclofen, 34 (97%) remained abstinent. There were no serious adverse events.
CONCLUSIONS: Baclofen's safety and efficacy in improving the clinical condition patients with alcoholic liver disease has been supported. Randomized prospective studies with longer duration of baclofen in this population may further optimize its use and corroborate efficacy.
Предметные рубрики MeSH
AdultAgedAged, 80 and overAlanine TransaminaseAlbuminsAlcohol AbstinenceAlcoholismAspartate AminotransferasesBaclofenBilirubinFemaleGABA-B Receptor AgonistsHepatitis, AlcoholicHumansInternational Normalized RatioLiverLiver Cirrhosis, AlcoholicMaleMiddle AgedProthrombin TimeRetrospective StudiesSeverity of Illness Index