The Journal of infectious diseases · 2023
The ROSA-Like Prophage Colonizing Staphylococcus aureus Promotes Intracellular Survival, Biofilm Formation, and Virulence in a Chronic Wound Environment.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Ahmad-Mansour Nour, Plumet Lucile, Pouget Cassandra, Kissa Karima, Dunyach-Remy Catherine, Sotto Albert, Lavigne Jean-Philippe, Molle Virginie
Аннотация
BACKGROUND: The transition from colonization to invasion is critical in diabetic foot ulcer (DFU). Staphylococcus aureus can colonize DFU, or invade the underlying tissues, causing serious infections. The ROSA-like prophage has previously been implicated in strain colonization characteristics of S aureus isolates in uninfected ulcers.
METHODS: In this study, we investigated this prophage in the S aureus-colonizing strain using an in vitro chronic wound medium mimicking the chronic wound environment.
RESULTS: Chronic wound medium reduced bacterial growth and increased biofilm formation and virulence in a zebrafish model.
CONCLUSIONS: The ROSA-like prophage promoted intracellular survival of S aureus-colonizing strain in macrophages, keratinocytes, and osteoblasts.
METHODS: In this study, we investigated this prophage in the S aureus-colonizing strain using an in vitro chronic wound medium mimicking the chronic wound environment.
RESULTS: Chronic wound medium reduced bacterial growth and increased biofilm formation and virulence in a zebrafish model.
CONCLUSIONS: The ROSA-like prophage promoted intracellular survival of S aureus-colonizing strain in macrophages, keratinocytes, and osteoblasts.