Oocyte cryopreservation and reciprocal in vitro fertilization in a transgender man on long term testosterone gender-affirming hormone therapy: a case report.

OBJECTIVE

To report a successful case of oocyte cryopreservation and subsequent in vitro fertilization (IVF) in a transgender male receiving continued testosterone gender-affirming hormone therapy, followed by reciprocal embryo transfer (ET).

DESIGN

A case report of a rare case of fertility preservation in a transgender man with concomitant use of testosterone therapy for 4 years before and during ovarian stimulation.

SETTING

Private fertility clinic with university affiliation.

PATIENTS: A 26-year-old transgender man undergoing oocyte cryopreservation before gender-affirming surgery.

INTERVENTIONS: Fertility preservation using oocyte cryopreservation and IVF with reciprocal fresh ET into a cisfemale partner.

MAIN OUTCOME MEASURES: Successful oocyte cryopreservation, oocyte thawing, and reciprocal IVF cycle.

RESULTS

Oocyte cryopreservation of 29 mature oocytes. Sixteen mature oocytes survived the thaw, and 12 were fertilized with intracytoplasmic sperm injection. A fresh ET of an advanced blastocyst resulted in a clinical pregnancy and live birth.

CONCLUSIONS

Fertility preservation with oocyte cryopreservation or IVF with embryo cryopreservation is feasible for patients on continued long-term testosterone gender-affirming therapy. Future studies on egg quality and reproductive outcomes are required. Our case report demonstrates a promising outcome in this patient population.