[Genetics in secondary hyperparathyroidism of uremia].

Little is known about genetic alterations in parathyroid hyperplasias in uremic patients. Although overexpression of cyclin D1 and inactivation of MEN1 gene are found in subsets of common parathyroid adenomas, specific oncogenes or tumor suppressor genes contributing to monoclonal uremic hyperparathyroidism have not yet been identified. On the other hand, some candidate gene polymorphisms have been suggested to play a key role in the pathogenesis of this disease.