Медицинская библиотека · Archives of oral biology · 2010

MMP1 and MMP20 contribute to tooth agenesis in humans.

Küchler Erika C, Menezes Renato, Callahan Nicholas, Costa Marcelo C, Modesto Adriana, Meira Raquel, Patir Asli, Seymen Figen, Paiva Katiúcia B S, Nunes Fabio Daumas, Granjeiro José Mauro, Vieira Alexandre R

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Аннотация

OBJECTIVE

Variations in genes that are critical for tooth formation may contribute to the tooth agenesis. MMPs are potential candidate genes for dental alterations based on the roles they play during embryogenesis. The aim of this study was to investigate the possible association between MMP1, MMP3, and MMP20 and tooth agenesis.

METHODS

One hundred sixty-seven nuclear families from two different populations were analysed, 116 from Brazil and 51 from Turkey. Probands had at least one congenitally missing tooth. DNA samples were obtained from blood or saliva samples and genotyping was performed using TaqMan chemistry. In addition, Mmp20 was selected for quantitative real-time polymerase chain reaction analysis with SYBR Green I Dye in mouse tooth development.

RESULTS

Associations between tooth agenesis and MMP1 (p=0.007), and MMP20 (p=0.03) were found in Brazilian families. In the total dataset, MMP20 continued to be associated with tooth agenesis (p=0.01). Mmp20 was not expressed during the initial stages of tooth development.

CONCLUSION

Our findings provide evidence that MMP1 and MMP20 play a role in human tooth agenesis.

Для цитирования: Küchler Erika C, Menezes Renato, Callahan Nicholas, Costa Marcelo C, Modesto Adriana, Meira Raquel, Patir Asli, Seymen Figen, Paiva Katiúcia B S, Nunes Fabio Daumas, Granjeiro José Mauro, Vieira Alexandre R. MMP1 and MMP20 contribute to tooth agenesis in humans.. Archives of oral biology. 2010. DOI: 10.1016/j.archoralbio.2010.11.007.

Предметные рубрики MeSH

Analysis of Variance Animals Anodontia Brazil Female Genotype Humans Male Matrix Metalloproteinase 1 Matrix Metalloproteinase 20 Matrix Metalloproteinase 3 Mice Odontogenesis Phenotype Polymorphism, Genetic Reverse Transcriptase Polymerase Chain Reaction Turkey

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