[The clinical laboratory characteristics of secretory function of thyroidal chain of regulation in individuals of dangerous professions].

The established opinions concerning etiology and pathogenesis of human health condition owing to impact of extreme factors indicate that stressing of regulatory systems (neuro-immune endocrinal complex) is a leading mechanism in their development. Just in the endocrine component failure of physiological bindings occurs in the system "central-peripheral internal secretion glands" followed by alteration of metabolism. The study was carried out to determine characteristics of content of levels of thyrotropic hormone, thyroxine and triiodothyronine in individuals of dangerous professions depending on level of implemented occupational load. Two series of studies was implemented among employees of the Interior ministry board - combatants, ordinary policemen and cadets. The examination began with the mission on the territory with armed conflict of combatants and continued after its completion. The blood serum was analyzed for establishing content of thyrotropic hormone, thyroxine and triiodothyronine. The highest level of thyrotropic hormone was detected in group of combatants in both studies. The levels of thyroxine and triiodothyronine were minimal in group of combatants prior to mission as compared with other groups and the highest ones after mission. Therefore, long-term alterations of secretory function of endocrine system resulting in hormonal imbalance can lead to breakdown of adaptation process. Thereupon, the system of medical support of individuals under effect of extreme negative professional factors requires development and adequate functioning of endocrinological component with the purpose of increasing resistance and viability of organism to the conditions of extreme impact of emergency situations and also preventing development of pathological conditions.