CJC open · 2026
Clinical and Echocardiographic Characteristics of Neuroendocrine Tumours and Carcinoid Heart Disease: Insights from a Contemporary Canadian Cohort.
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Yoon Joshua, Yeung Cynthia, Wong Jeffrey D, Mazengarb Janine, Luong Christina L, Tsang Michael Y C, Tsang Teresa S M, Davis Margot K, Gin Kenneth, Jue John, Nair Parvathy, Loree Jonathan M, Yeung Darwin F
Аннотация
BACKGROUND: Neuroendocrine tumours (NETs) are uncommon cancers that secrete vasoactive hormones. Around half of those with metastatic small bowel NETs develop carcinoid syndrome, and historically, up to 50% develop carcinoid heart disease (CHD). We evaluated clinical characteristics, echocardiographic features, and outcomes of patients with NETs and CHD in a contemporary cohort to identify factors associated with CHD development and mortality.
METHODS: We identified patients with NETs who underwent an echocardiogram at a tertiary cancer centre-affiliated laboratory (2013-2023). Patients were classified based on whether they developed CHD. Clinical characteristics, echocardiographic data within 6 months of NET diagnosis, treatments, and outcomes were compared between CHD and non-CHD patients.
RESULTS: Over a 10-year period, 87 patients with NETs were identified (48% female; median age, 61 years), with 18 (21%) developing CHD. Primary small bowel NETs were more common with CHD (83% vs 55%, P = 0.032). Patients with CHD exclusively had right-sided valve involvement: 100% tricuspid, 61% pulmonary, and 0% mitral/aortic; 17% had a patent foramen ovale. Compared to non-CHD patients, CHD patients demonstrated higher right atrial volume index and right ventricular basal diameter, with more frequent right ventricular dysfunction. Patients with CHD had a lower median survival from the time of NET diagnosis (6.6 vs 13.4 years; P = 0.007). Among CHD patients, primary NET resection was associated with improved survival (P = 0.006).
CONCLUSIONS: Within a contemporary cohort, approximately 1 in 5 patients with NETs develop CHD and exhibit only right-sided valve involvement. CHD was associated with increased mortality whereas primary NET resection was associated with improved survival.
METHODS: We identified patients with NETs who underwent an echocardiogram at a tertiary cancer centre-affiliated laboratory (2013-2023). Patients were classified based on whether they developed CHD. Clinical characteristics, echocardiographic data within 6 months of NET diagnosis, treatments, and outcomes were compared between CHD and non-CHD patients.
RESULTS: Over a 10-year period, 87 patients with NETs were identified (48% female; median age, 61 years), with 18 (21%) developing CHD. Primary small bowel NETs were more common with CHD (83% vs 55%, P = 0.032). Patients with CHD exclusively had right-sided valve involvement: 100% tricuspid, 61% pulmonary, and 0% mitral/aortic; 17% had a patent foramen ovale. Compared to non-CHD patients, CHD patients demonstrated higher right atrial volume index and right ventricular basal diameter, with more frequent right ventricular dysfunction. Patients with CHD had a lower median survival from the time of NET diagnosis (6.6 vs 13.4 years; P = 0.007). Among CHD patients, primary NET resection was associated with improved survival (P = 0.006).
CONCLUSIONS: Within a contemporary cohort, approximately 1 in 5 patients with NETs develop CHD and exhibit only right-sided valve involvement. CHD was associated with increased mortality whereas primary NET resection was associated with improved survival.