Nature clinical practice. Gastroenterology & hepatology · 2008
A case of hearing loss associated with pegylated interferon and ribavirin treatment ameliorated by prednisone.
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Le Vu, Bader Ted, Fazili Javid
Аннотация
BACKGROUND: A 51-year-old white man with chronic obstructive pulmonary disease who was infected with HCV genotype 2b presented with sudden left-sided hearing loss. He had been taking pegylated interferon (PEG-IFN) and ribavirin treatment for 6 weeks without any notable adverse effects. He had also been taking naproxen for 2 years for the treatment of chronic back pain.
INVESTIGATIONS: Physical examination, laboratory tests, including complete blood counts and liver function tests, otoscopic examination, audiogram, MRI of the middle ear, objective causality assessment using the Naranjo probability scale.
DIAGNOSIS: PEG-IFN-induced acute sensorineural hearing loss.
MANAGEMENT: Prednisone while maintaining treatment with PEG-IFN.
INVESTIGATIONS: Physical examination, laboratory tests, including complete blood counts and liver function tests, otoscopic examination, audiogram, MRI of the middle ear, objective causality assessment using the Naranjo probability scale.
DIAGNOSIS: PEG-IFN-induced acute sensorineural hearing loss.
MANAGEMENT: Prednisone while maintaining treatment with PEG-IFN.